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KMID : 0363220090470010111
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Korean Journal of Dermatology
2009 Volume.47 No. 1 p.111 ~ p.114
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Treatment of Granuloma Faciale with Steroid Intralesional Injection Followed by a Topical Application of Tacrolimus
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Lee Ji-Hyun
Kim Hyung-Ok
Song Kye-Yong
Park Young-Min
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Abstract
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Granuloma faciale is an uncommon disease of an unknown origin, and it is characterized by single or multiple
erythematous facial skin lesions. Histologically, a narrow Grenz zone of normal dermis is observed between the
epidermis and the dense dermal polymorphous infiltrates. The course of granuloma faciale is chronic and the
response to therapy is usually poor. We report here a case of granuloma faciale in a 37-year-old male who presented
with a 13-year history of a solitary, red-brown, soft, elevated, irregular shaped plaque on the chin. The biopsy
specimen showed a Grenz zone and a dense, dermal infiltrate of mononuclear cells mixed with numerous eosinophils
and neutrophils that displayed a diffuse and perivascular pattern. After 4 courses of intralesional steroid injection, the
lesion almost became flattened, although it remained a pinkish patch. The lesion almost cleared up after 4 months
of applying 0.03% topical tacrolimus.
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KEYWORD
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Granuloma faciale, Intralesional steroid injection, Topical tacrolimus
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